There’s no confirmation that Peyton Manning will miss more than a game, but it’s becoming obvious that this won’t be a one-week hiatus from the Indianapolis lineup. The Colts confirmed today that No. 18 won’t play Sunday in Houston, which has us thinking that he’ll be very doubtful for Week 2′s home opener against the Cleveland Browns.

A somber statement from Manning:

“To say I am disappointed in not being able to play is an understatement. The best part about football is being out there on the field playing with my teammates. It will be tough not to be out there playing for the organization and our fans. I simply am not healthy enough to play, and I am doing everything I can to get my health back. The team will do fine without me, and I know for sure that I will miss them much more than they will miss me.”

So the Kerry Collins era begins. And if it lasts more than a few weeks, the Colts’ season could go up in flames.