Looks like Jim Irsay picked the wrong week to quit sniffing glue.

NFL Network’s Jason La Canfora and ESPN’s Chris Mortensen are reporting that Peyton Manning has indeed undergone a third procedure on his neck and is expected to miss 2-3 months, minimum. We’re yet to hear if Peyton will go on the injured reserve, but it seems likely that No. 18 will miss much or all of the 2011 season.

UPDATE: Here’s a statement from the Colts…

As previously stated on Monday, Sept. 5th, Peyton Manning has undergone further testing and consultation with several specialists regarding his rehabilitation. The results of these tests and the consensus of the consultations was that further surgery was warranted. Peyton has undergone this surgery today by having a single level anterior fusion. The surgery was un-eventful.

This procedure is performed regularly throughout the country on persons from all walks of life, including professional football players. Two former Colts players had this same procedure last winter and have fully resumed their careers. Rehabilitation from such surgery is typically an involved process. Therefore, there will be no estimation of a return date at this time. We will keep Peyton on the active roster until we have a clearer picture of his recovery process.

Peyton will immediately begin the rehabilitation regimen mapped out by the surgeon.

So the Colts will ride or die with Kerry Collins and/or Curtis Painter this year, unless they decide to throw Jake Delhomme or David Garrard into the fire as well.

Collins will get the first kick at the can with a start this Sunday in Houston. The 38-year-old had 14 touchdowns and eight interceptions in seven starts with Tennessee last year.

It’ll likely be a lost year in Indianapolis, which is tough because the Super Bowl is being played in Indy in February. Considering what happened to the Cowboys at this point last year, I’m starting to wonder about a Super Bowl hosting curse. Watch out, New Orleans — you’re up next.