Here are the top five games of Week 6, a list that is led by a matchup between the two most surprising teams in football:

(Team rankings are based on ourĀ latest power rankings.)

1. No. 11 49ers at No. 3 Lions (Sunday, 1:00 ET on Fox)

How in the world are the Niners and Lions a combined 9-1? Detroit looks to move to 6-0 and match its best start since 1934 against the same team it beat to move to 6-0 in 1956. The Niners have already won two games in the Eastern time zone, and the Lions could be primed to have a letdown game on short rest following an emotional prime-time victory over a division rival. This will be a very good game.

2. No. 7 Bills at No. 19 Giants (Sunday, 1:00 ET on CBS)

Buffalo can secure a 5-1 record and first place in the AFC East headed into the bye week. All they have to do is win where the Seahawks were able to win in Week 5. The Giants are a banged-up disaster with wins over three teams with a combined record of 2-12. This is a very winnable game for the exciting Bills.

3. No. 18 Cowboys at No. 2 Patriots (Sunday, 4:15 ET on Fox)

Great matchup between two of America’s favorite teams. Dallas is healthy again after the bye but the Patriots haven’t lost a regular-season home game since 2008, and the Patriots are also getting healthier by the week.

4. No. 22 Eagles at No. 13 Redskins (Sunday, 1:00 ET on Fox)

Philadelphia is trying to save its Dream Team season against a hot Redskins team coming off a bye at home. Wrong place, wrong time for Philly, which is considerably more banged up than the ‘Skins. But with Rex Grossman under center for the inexperienced Redskins, anything can happen.

5. No. 9 Texans at No. 5 Ravens (Sunday, 4:05 ET on CBS)

This is one matchup that might look a bit better on paper than on the field, but it’s still a battle between two division leaders. Baltimore is rested off the bye, while the Texans are sort of reeling without their best offensive player (Andre Johnson) and their best defensive player (Mario Williams). It’ll be interesting to see how Houston reacts to adversity against a quality opponent like Baltimore.

Honorable mention: Saints-Buccaneers