That sound you heard a little while ago was a collective struggle for oxygen by C.J. Spiller owners. Or maybe it was just Devang Desai slamming the door shut while crawling into the nearest freezer.

Spiller fell awkwardly on his shoulder in the second quarter of Buffalo’s game this afternoon against the Browns, and after being examined on the sideline the Bills announced that he won’t return. Although he had been quiet on the ground with only four carries for 16 yards, Spiller contributed to his team’s 14-7 first-half lead with a 32-yard touchdown reception.

Beyond proving definitively that Bills fans can’t have nice things, this is potentially crushing for fantasy owners who thought they had this year’s breakout running back, a player who was purchased during drafts at an extremely low late-round price, and sometimes even available on the waiver wire a few weeks. Spiller had 364 all-purpose yards through two weeks, 292 of which came on the ground. And including today’s score, he has three touchdowns in three games.

There’s been some murmurs about Fred Jackson possibly making a quick comeback from his knee injury and playing next week. For now, though, the Bills’ default running back is Tashard Choice, making him the waiver wire pickup this week for the mentally mangled Bills RB owner who’s grasping for a life line.

Oh also, Reggie Bush and his 234 rushing yards over his last six quarters of football left Miami’s game with a knee injury in the second quarter, and he hasn’t returned yet. Stay safe out there, you guys.

UPDATE: Spiller has a separated shoulder. He’ll have an MRI tomorrow to determine the severity of the separation and a timetable for his return, according to Jason La Canfora.